#Head information NAME 4ab0 TYPE alpha-beta REPRESENTATIVE 8abp_42 MEMBERS 31 CLUSTER 5 #Loop element > 8abp_42 .........gektlnaidslaaSGAKgfvic... 4ab0_0.pdb 0 > 1gca_45 .........qskqndqidvllaKGVKalai.... 4ab0_1.pdb 1 > 2liv_55 .........pkqavavankvvnDGIKyvig.... 4ab0_2.pdb 0 > 1thm_112 .........wtavangityaadQGAKvisl.... 4ab0_3.pdb 1 > 3chy_38 ............gvdalnklqaGGYGfvisd... 4ab0_4.pdb 2 >1nba-A_149 ...............lelfltsNRIDtlivtga. 4ab0_5.pdb 0 >1min-B_426 ............lwhlrslvftDKPDfmig.... 4ab0_6.pdb 3 >1lcp-A_89 ........iraavaagcrqiqdLEIPsvev.... 4ab0_7.pdb 0 >1bpl-A_27 ................saylaeHGITavw..... 4ab0_8.pdb 0 > 1oyc_169 ........yikeyvqaaknsiaAGADgveih... 4ab0_9.pdb 1 > 1xis_114 ........alrktirnidlaveLGAEtyva.... 4ab0_10.pdb 0 > 2mnr_142 ........gvklateravtaaeLGFRavktk... 4ab0_11.pdb 0 > 2liv_183 .............stlvarlkkENIDfvyyg... 4ab0_12.pdb 0 >2sec-E_103 .........ysgivsgiewattNGMDvinm.... 4ab0_13.pdb 1 > 1sup_104 .........yswiingiewaiaNNMDvinm.... 4ab0_14.pdb 1 > 1st3_102 .........issiaqglewagnNGMHvanl.... 4ab0_15.pdb 1 >3eca-A_226 ..............lpakalvdAGYDgivsagv. 4ab0_16.pdb 1 >1nal-1_21 .........kaslrrlvqfniqQGIDglyv.... 4ab0_17.pdb 1 >2tmd-A_38 .........pgfqsahrsvkaeGGWAalnt.... 4ab0_18.pdb 1 > 1cbg_71 ........eyhrykedigimkdMNLDayrfs... 4ab0_19.pdb 0 > 1frb_24 .........pnqvkeavkaaidAGYRhid..... 4ab0_20.pdb 0 >1bgl-A_367 .........eqtmvqdillmkqNNFNavr..... 4ab0_21.pdb 0 >1isd-B_169 .............teayiralcKGCRcleld... 4ab0_22.pdb 0 > 1gym_55 ................fryqmdHGARifdirgrl 4ab0_23.pdb 0 > 1mla_255 ............wtksveymaaQGVEhlye.... 4ab0_24.pdb 0 >1nal-1_82 .........taesqqlaasakrYGFDavsav... 4ab0_25.pdb 1 > 1pii_120 .............pyqiylaryYQADacllm... 4ab0_26.pdb 0 >2ohx-A_202 ..........gvglsvimgckaAGAAriigv... 4ab0_27.pdb 1 > 1udh_152 ..........fvggvirrlaarRPGLvfml.... 4ab0_28.pdb 4 >1xyl-B_108 ..rdvrryalrktirnidlaveLGAKtyva.... 4ab0_29.pdb 0 >1xlk-A_107 ..rsirrfalakvlhnidlaaeMGAEtfvm.... 4ab0_30.pdb 0 #Motif sequence .........GEKTLNAIDSLAASGAKGFVIC... .........QSKQNDQIDVLLAKGVKALAI.... .........PKQAVAVANKVVNDGIKYVIG.... .........WTAVANGITYAADQGAKVISL.... ............GVDALNKLQAGGYGFVISD... ...............LELFLTSNRIDTLIVTGA. ............LWHLRSLVFTDKPDFMIG.... ........IRAAVAAGCRQIQDLEIPSVEV.... ................SAYLAEHGITAVW..... ........YIKEYVQAAKNSIAAGADGVEIH... ........ALRKTIRNIDLAVELGAETYVA.... ........GVKLATERAVTAAELGFRAVKTK... .............STLVARLKKENIDFVYYG... .........YSGIVSGIEWATTNGMDVINM.... .........YSWIINGIEWAIANNMDVINM.... .........ISSIAQGLEWAGNNGMHVANL.... ..............LPAKALVDAGYDGIVSAGV. .........KASLRRLVQFNIQQGIDGLYV.... .........PGFQSAHRSVKAEGGWAALNT.... ........EYHRYKEDIGIMKDMNLDAYRFS... .........PNQVKEAVKAAIDAGYRHID..... .........EQTMVQDILLMKQNNFNAVR..... .............TEAYIRALCKGCRCLELD... ................FRYQMDHGARIFDIRGRL ............WTKSVEYMAAQGVEHLYE.... .........TAESQQLAASAKRYGFDAVSAV... .............PYQIYLARYYQADACLLM... ..........GVGLSVIMGCKAAGAARIIGV... ..........FVGGVIRRLAARRPGLVFML.... ..RDVRRYALRKTIRNIDLAVELGAKTYVA.... ..RSIRRFALAKVLHNIDLAAEMGAETFVM.... #Loop sequence SGAK KGVK DGIK QGAK GGYG NRID DKPD LEIP HGIT AGAD LGAE LGFR ENID NGMD NNMD NGMH AGYD QGID GGWA MNLD AGYR NNFN KGCR HGAR QGVE YGFD YQAD AGAA RPGL LGAK MGAE #Fingerprint N G A D : : : : : : : : : : : : : : : : A : : : : : : : : : : : : : : : L : I : : : : : : : : K : : : : Q : : : : : : : : : F : D : : R : : : : G : M : : : : : H : : E : : Y : K N : : : : : A M : V : : : : G Y E C H : K G L E P L N R Q P P S R W T #Geometry parameters DISTANCE 10.27 ( 0.42) Vector1 ( 0.29 -0.95 -0.11) Vector2 ( -0.46 0.89 -0.09) Vector3 ( 0.81 0.44 -0.40) Struc diversity(A) ( 3.8 3.7 4.1 4.4) #Key residues 0.1 0.1 0.1 0.1) 0.1 0.1 0.1 0.1) #RMSD matrix of conformation of loops (A) 0.00 0.88 0.49 0.57 2.74 0.64 1.86 0.58 0.92 1.00 0.18 0.77 0.88 0.88 0.74 0.70 1.18 1.00 1.24 0.35 0.80 0.69 0.71 0.77 0.83 0.92 0.48 1.01 2.89 0.29 0.31 0.88 0.00 1.21 0.47 2.16 1.05 1.20 1.27 1.49 1.02 0.93 1.49 1.30 0.43 0.29 0.31 0.67 0.54 0.98 0.73 1.36 1.38 1.25 1.41 1.40 0.50 1.27 0.48 2.81 1.07 0.95 0.49 1.21 0.00 0.87 2.89 0.53 2.03 0.75 0.62 1.18 0.49 0.82 0.85 1.16 1.03 1.01 1.46 1.26 1.44 0.71 0.70 0.49 0.83 0.58 0.63 1.23 0.54 1.32 2.90 0.43 0.58 0.57 0.47 0.87 0.00 2.43 0.88 1.53 1.00 1.16 0.76 0.62 1.08 1.17 0.43 0.46 0.31 0.86 0.56 0.84 0.58 0.97 1.02 1.02 1.03 1.02 0.54 0.90 0.62 2.93 0.73 0.67 2.74 2.16 2.89 2.43 0.00 2.74 2.33 2.96 3.05 2.65 2.71 3.18 3.03 2.28 2.28 2.29 2.31 2.32 2.53 2.55 2.99 3.00 2.86 2.97 3.00 2.41 3.01 2.24 3.02 2.82 2.70 0.64 1.05 0.53 0.88 2.74 0.00 1.68 1.01 0.76 1.36 0.68 1.26 0.53 1.11 0.86 0.95 1.36 1.26 1.55 0.74 1.05 0.87 1.00 0.96 0.93 1.22 0.91 1.25 2.81 0.71 0.76 1.86 1.20 2.03 1.53 2.33 1.68 0.00 2.23 2.17 1.94 1.94 2.50 1.78 1.41 1.30 1.39 1.40 1.39 1.78 1.73 2.28 2.26 2.22 2.30 2.21 1.41 2.27 1.40 2.96 2.05 1.92 0.58 1.27 0.75 1.00 2.96 1.01 2.23 0.00 1.27 1.33 0.60 0.73 1.14 1.34 1.12 1.13 1.44 1.40 1.56 0.67 1.08 0.99 0.69 1.00 1.19 1.28 0.59 1.34 2.80 0.62 0.51 0.92 1.49 0.62 1.16 3.05 0.76 2.17 1.27 0.00 1.39 0.88 1.12 0.99 1.39 1.38 1.33 1.82 1.54 1.67 1.17 0.80 0.62 1.24 0.68 0.47 1.54 0.88 1.64 3.20 0.79 1.04 1.00 1.02 1.18 0.76 2.65 1.36 1.94 1.33 1.39 0.00 0.96 1.02 1.71 0.69 1.02 0.79 1.08 0.67 0.44 1.10 0.80 1.04 1.13 0.99 1.02 0.67 1.03 0.84 3.28 0.98 1.15 0.18 0.93 0.49 0.62 2.71 0.68 1.94 0.60 0.88 0.96 0.00 0.71 0.96 0.91 0.81 0.75 1.23 1.03 1.24 0.43 0.72 0.62 0.65 0.67 0.76 0.96 0.40 1.05 2.90 0.18 0.35 0.77 1.49 0.82 1.08 3.18 1.26 2.50 0.73 1.12 1.02 0.71 0.00 1.47 1.35 1.38 1.26 1.64 1.40 1.37 1.01 0.65 0.71 0.85 0.67 0.85 1.32 0.40 1.47 3.21 0.62 0.82 0.88 1.30 0.85 1.17 3.03 0.53 1.78 1.14 0.99 1.71 0.96 1.47 0.00 1.42 1.15 1.26 1.65 1.58 1.89 0.96 1.40 1.19 1.30 1.31 1.25 1.50 1.13 1.57 2.95 1.00 0.93 0.88 0.43 1.16 0.43 2.28 1.11 1.41 1.34 1.39 0.69 0.91 1.35 1.42 0.00 0.50 0.28 0.75 0.30 0.67 0.82 1.14 1.21 1.25 1.25 1.20 0.37 1.19 0.49 3.01 1.02 1.00 0.74 0.29 1.03 0.46 2.28 0.86 1.30 1.12 1.38 1.02 0.81 1.38 1.15 0.50 0.00 0.27 0.60 0.63 1.01 0.61 1.24 1.23 1.06 1.28 1.29 0.55 1.14 0.49 2.71 0.93 0.85 0.70 0.31 1.01 0.31 2.29 0.95 1.39 1.13 1.33 0.79 0.75 1.26 1.26 0.28 0.27 0.00 0.65 0.40 0.81 0.61 1.11 1.13 1.07 1.17 1.17 0.37 1.07 0.42 2.83 0.87 0.82 1.18 0.67 1.46 0.86 2.31 1.36 1.40 1.44 1.82 1.08 1.23 1.64 1.65 0.75 0.60 0.65 0.00 0.71 0.89 1.10 1.48 1.57 1.22 1.56 1.63 0.59 1.48 0.33 2.75 1.31 1.32 1.00 0.54 1.26 0.56 2.32 1.26 1.39 1.40 1.54 0.67 1.03 1.40 1.58 0.30 0.63 0.40 0.71 0.00 0.57 0.93 1.21 1.31 1.32 1.33 1.31 0.24 1.29 0.45 3.01 1.13 1.11 1.24 0.98 1.44 0.84 2.53 1.55 1.78 1.56 1.67 0.44 1.24 1.37 1.89 0.67 1.01 0.81 0.89 0.57 0.00 1.27 1.15 1.39 1.37 1.34 1.35 0.60 1.36 0.71 3.27 1.29 1.38 0.35 0.73 0.71 0.58 2.55 0.74 1.73 0.67 1.17 1.10 0.43 1.01 0.96 0.82 0.61 0.61 1.10 0.93 1.27 0.00 1.07 0.95 0.88 1.05 1.10 0.85 0.76 0.94 2.74 0.60 0.30 0.80 1.36 0.70 0.97 2.99 1.05 2.28 1.08 0.80 0.80 0.72 0.65 1.40 1.14 1.24 1.11 1.48 1.21 1.15 1.07 0.00 0.37 0.84 0.26 0.38 1.19 0.58 1.30 3.24 0.59 0.99 0.69 1.38 0.49 1.02 3.00 0.87 2.26 0.99 0.62 1.04 0.62 0.71 1.19 1.21 1.23 1.13 1.57 1.31 1.39 0.95 0.37 0.00 0.87 0.29 0.33 1.29 0.54 1.40 3.11 0.49 0.86 0.71 1.25 0.83 1.02 2.86 1.00 2.22 0.69 1.24 1.13 0.65 0.85 1.30 1.25 1.06 1.07 1.22 1.32 1.37 0.88 0.84 0.87 0.00 0.79 1.06 1.19 0.63 1.15 2.85 0.60 0.87 0.77 1.41 0.58 1.03 2.97 0.96 2.30 1.00 0.68 0.99 0.67 0.67 1.31 1.25 1.28 1.17 1.56 1.33 1.34 1.05 0.26 0.29 0.79 0.00 0.35 1.30 0.54 1.38 3.13 0.52 0.93 0.83 1.40 0.63 1.02 3.00 0.93 2.21 1.19 0.47 1.02 0.76 0.85 1.25 1.20 1.29 1.17 1.63 1.31 1.35 1.10 0.38 0.33 1.06 0.35 0.00 1.32 0.71 1.44 3.24 0.64 1.01 0.92 0.50 1.23 0.54 2.41 1.22 1.41 1.28 1.54 0.67 0.96 1.32 1.50 0.37 0.55 0.37 0.59 0.24 0.60 0.85 1.19 1.29 1.19 1.30 1.32 0.00 1.21 0.36 2.96 1.06 1.04 0.48 1.27 0.54 0.90 3.01 0.91 2.27 0.59 0.88 1.03 0.40 0.40 1.13 1.19 1.14 1.07 1.48 1.29 1.36 0.76 0.58 0.54 0.63 0.54 0.71 1.21 0.00 1.32 3.08 0.31 0.58 1.01 0.48 1.32 0.62 2.24 1.25 1.40 1.34 1.64 0.84 1.05 1.47 1.57 0.49 0.49 0.42 0.33 0.45 0.71 0.94 1.30 1.40 1.15 1.38 1.44 0.36 1.32 0.00 2.85 1.14 1.15 2.89 2.81 2.90 2.93 3.02 2.81 2.96 2.80 3.20 3.28 2.90 3.21 2.95 3.01 2.71 2.83 2.75 3.01 3.27 2.74 3.24 3.11 2.85 3.13 3.24 2.96 3.08 2.85 0.00 2.95 2.83 0.29 1.07 0.43 0.73 2.82 0.71 2.05 0.62 0.79 0.98 0.18 0.62 1.00 1.02 0.93 0.87 1.31 1.13 1.29 0.60 0.59 0.49 0.60 0.52 0.64 1.06 0.31 1.14 2.95 0.00 0.49 0.31 0.95 0.58 0.67 2.70 0.76 1.92 0.51 1.04 1.15 0.35 0.82 0.93 1.00 0.85 0.82 1.32 1.11 1.38 0.30 0.99 0.86 0.87 0.93 1.01 1.04 0.58 1.15 2.83 0.49 0.00 #Sequence identities difference matrix of loop (%) 0.0 50.0 50.0 25.0 75.0100.0100.0100.0 75.0 50.0 50.0 75.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 50.0 75.0 75.0 75.0 50.0100.0 25.0 50.0 50.0 0.0 50.0 50.0 75.0100.0100.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 50.0 75.0 50.0 75.0100.0 75.0100.0 50.0 75.0 50.0 50.0 0.0 50.0 75.0 75.0 75.0 75.0 50.0 75.0 75.0 75.0 75.0 75.0100.0 75.0 75.0 50.0 75.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 50.0 75.0 25.0 50.0 50.0 0.0 75.0100.0100.0100.0 75.0 50.0 50.0 75.0100.0 75.0100.0 75.0 75.0 50.0 75.0100.0 75.0100.0 75.0 50.0 50.0 75.0 75.0 50.0100.0 25.0 50.0 75.0 75.0 75.0 75.0 0.0100.0100.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 50.0 75.0 50.0100.0 50.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 75.0 100.0100.0 75.0100.0100.0 0.0 75.0 75.0 75.0 75.0100.0100.0 50.0 50.0 50.0 75.0 75.0 50.0100.0 75.0100.0 75.0100.0100.0100.0 75.0 75.0100.0100.0100.0100.0 100.0100.0 75.0100.0100.0 75.0 0.0100.0100.0 75.0100.0100.0 75.0 75.0 75.0100.0 75.0 75.0100.0 75.0100.0100.0100.0100.0100.0 75.0 75.0100.0100.0100.0100.0 100.0100.0 75.0100.0100.0 75.0100.0 0.0 75.0100.0 75.0 75.0 75.0100.0100.0100.0100.0 75.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0 75.0100.0 75.0 75.0 50.0 75.0 75.0 75.0100.0 75.0 0.0 75.0 75.0 75.0 75.0 75.0100.0 75.0 75.0 50.0 75.0100.0 75.0100.0 75.0 50.0 75.0 75.0100.0 75.0100.0 75.0 75.0 50.0 75.0 75.0 50.0 75.0 75.0 75.0100.0 75.0 0.0 50.0 75.0 75.0 50.0 75.0 75.0 25.0 50.0 75.0 75.0 50.0100.0 75.0 50.0 75.0 50.0 50.0 25.0100.0 50.0 50.0 50.0 75.0 75.0 50.0 75.0100.0100.0 75.0 75.0 50.0 0.0 50.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 50.0 50.0 75.0 75.0 50.0100.0 25.0 25.0 75.0 75.0 75.0 75.0 75.0100.0100.0 75.0 75.0 75.0 50.0 0.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 50.0 75.0 50.0 50.0 75.0 50.0100.0 75.0100.0 50.0 75.0 100.0100.0 75.0100.0100.0 50.0 75.0 75.0 75.0 75.0100.0100.0 0.0 75.0 50.0100.0 75.0 50.0100.0 50.0100.0 75.0100.0100.0100.0 75.0 75.0100.0100.0100.0100.0 75.0 75.0 75.0 75.0 75.0 50.0 75.0100.0 75.0 50.0 75.0 75.0 75.0 0.0 25.0 25.0 50.0 50.0 75.0 75.0 75.0 75.0 75.0 75.0 75.0 50.0 75.0 75.0100.0 75.0 75.0 100.0100.0100.0100.0100.0 50.0 75.0100.0100.0 75.0100.0100.0 50.0 25.0 0.0 50.0 75.0 75.0100.0 50.0100.0 50.0100.0100.0100.0 75.0 75.0100.0100.0100.0100.0 75.0 75.0 75.0 75.0 75.0 75.0100.0100.0 75.0 75.0 75.0 75.0100.0 25.0 50.0 0.0 75.0 75.0 75.0100.0 75.0 75.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 75.0 75.0 75.0 75.0 75.0 50.0 75.0 75.0100.0 75.0 25.0 75.0 75.0 75.0 50.0 75.0 75.0 0.0 50.0 75.0 75.0 25.0100.0 75.0 75.0 75.0 50.0 75.0 50.0100.0 75.0 75.0 75.0 75.0 50.0 50.0 75.0 50.0 75.0 75.0 50.0 50.0 75.0 75.0 50.0 50.0 75.0 75.0 50.0 0.0 75.0 75.0 75.0100.0 75.0 75.0 50.0 50.0 75.0 75.0100.0 75.0 75.0 75.0 75.0 75.0 75.0 50.0100.0100.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 75.0 75.0 0.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 50.0100.0 75.0 75.0 100.0100.0100.0100.0100.0 75.0 75.0100.0100.0 75.0100.0100.0 50.0 75.0 50.0100.0 75.0 75.0100.0 0.0100.0 75.0100.0100.0100.0 75.0 75.0100.0100.0100.0 75.0 75.0 75.0 75.0 75.0 50.0100.0100.0100.0 75.0 50.0 75.0 50.0100.0 75.0100.0 75.0 25.0 75.0 75.0100.0 0.0100.0 50.0 50.0 75.0 75.0100.0 50.0100.0 75.0 75.0 100.0100.0100.0100.0100.0 75.0100.0100.0100.0100.0100.0 75.0 75.0 75.0 50.0 75.0100.0100.0100.0 75.0100.0 0.0100.0100.0100.0 75.0100.0100.0100.0100.0100.0 75.0 50.0 75.0 75.0 75.0100.0100.0100.0 75.0 75.0 75.0 50.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 50.0100.0 0.0 50.0 75.0 75.0100.0 75.0100.0 75.0 75.0 50.0 75.0 75.0 50.0 75.0100.0100.0100.0 50.0 50.0 50.0 50.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 50.0100.0 50.0 0.0 75.0 75.0 75.0 50.0100.0 50.0 50.0 75.0 50.0 75.0 50.0 75.0100.0100.0100.0 75.0 75.0 50.0 75.0100.0 75.0100.0 75.0 75.0 50.0 75.0100.0 75.0100.0 75.0 75.0 0.0 75.0100.0 75.0100.0 75.0 50.0 75.0 75.0 75.0 75.0 75.0 75.0 75.0100.0 75.0 50.0 75.0 50.0 75.0 50.0 75.0 75.0 50.0 50.0 75.0 75.0 75.0 75.0 75.0 75.0 75.0 0.0 50.0 75.0100.0 75.0 75.0 75.0100.0100.0 75.0100.0 75.0 75.0100.0100.0 50.0 75.0100.0 75.0 75.0 75.0100.0 75.0 75.0100.0 75.0100.0100.0100.0 75.0100.0 50.0 0.0 75.0100.0 75.0 75.0 50.0 75.0 75.0 50.0 75.0100.0100.0100.0 75.0 25.0 50.0 75.0100.0 75.0100.0 75.0 50.0 75.0 50.0100.0 50.0100.0 75.0 50.0 75.0 75.0 75.0 0.0100.0 50.0 50.0 100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0 0.0100.0100.0 25.0 50.0 50.0 25.0 75.0100.0100.0 75.0 75.0 50.0 25.0 50.0100.0 75.0100.0 75.0 75.0 75.0 75.0100.0 75.0100.0 75.0 50.0 75.0 75.0 75.0 50.0100.0 0.0 50.0 50.0 75.0 75.0 50.0 75.0100.0100.0100.0 75.0 50.0 25.0 75.0100.0 75.0100.0 75.0 75.0 75.0 75.0 75.0 75.0100.0 75.0 50.0 50.0 75.0 75.0 50.0100.0 50.0 0.0 #Sequence identities difference matrix of motif (%) 0.0 41.0 59.0 47.0 46.0 68.0 51.0 68.0 56.0 50.0 47.0 62.0 62.0 59.0 56.0 62.0 59.0 59.0 53.0 65.0 59.0 62.0 59.0 62.0 56.0 59.0 59.0 50.0 50.0 62.0 59.0 41.0 0.0 56.0 53.0 53.0 65.0 62.0 65.0 53.0 59.0 53.0 62.0 62.0 53.0 53.0 56.0 65.0 56.0 47.0 62.0 59.0 56.0 53.0 68.0 50.0 59.0 50.0 56.0 53.0 68.0 71.0 59.0 56.0 0.0 49.0 47.0 65.0 50.0 49.0 53.0 53.0 59.0 53.0 59.0 56.0 62.0 56.0 62.0 56.0 53.0 65.0 53.0 56.0 62.0 71.0 59.0 56.0 58.0 53.0 63.0 74.0 79.0 47.0 53.0 49.0 0.0 62.0 71.0 62.0 50.0 53.0 62.0 53.0 59.0 65.0 44.0 44.0 44.0 62.0 56.0 56.0 62.0 47.0 59.0 56.0 62.0 50.0 51.0 53.0 53.0 50.0 68.0 65.0 46.0 53.0 47.0 62.0 0.0 56.0 50.0 62.0 47.0 51.0 65.0 62.0 47.0 59.0 62.0 58.0 50.0 60.0 54.0 65.0 56.0 59.0 47.0 57.0 50.0 59.0 56.0 50.0 49.0 82.0 80.0 68.0 65.0 65.0 71.0 56.0 0.0 53.0 68.0 47.0 71.0 71.0 74.0 47.0 62.0 65.0 68.0 47.0 53.0 68.0 71.0 71.0 65.0 56.0 53.0 59.0 65.0 56.0 65.0 68.0 88.0 88.0 51.0 62.0 50.0 62.0 50.0 53.0 0.0 63.0 53.0 65.0 62.0 66.0 47.0 56.0 59.0 67.0 54.0 53.0 56.0 65.0 62.0 61.0 56.0 65.0 50.0 59.0 50.0 56.0 50.0 79.0 76.0 68.0 65.0 49.0 50.0 62.0 68.0 63.0 0.0 59.0 51.0 62.0 60.0 62.0 62.0 62.0 59.0 71.0 54.0 63.0 65.0 59.0 62.0 59.0 71.0 65.0 62.0 68.0 62.0 58.0 70.0 76.0 56.0 53.0 53.0 53.0 47.0 47.0 53.0 59.0 0.0 62.0 59.0 53.0 41.0 59.0 62.0 59.0 50.0 56.0 50.0 65.0 56.0 53.0 50.0 44.0 44.0 53.0 43.0 59.0 56.0 76.0 74.0 50.0 59.0 53.0 62.0 51.0 71.0 65.0 51.0 62.0 0.0 62.0 56.0 62.0 59.0 59.0 59.0 56.0 56.0 56.0 62.0 53.0 59.0 59.0 68.0 62.0 50.0 62.0 56.0 58.0 79.0 79.0 47.0 53.0 59.0 53.0 65.0 71.0 62.0 62.0 59.0 62.0 0.0 56.0 68.0 56.0 56.0 59.0 65.0 59.0 58.0 62.0 59.0 59.0 62.0 71.0 59.0 59.0 56.0 59.0 56.0 21.0 41.0 62.0 62.0 53.0 59.0 62.0 74.0 66.0 60.0 53.0 56.0 56.0 0.0 65.0 57.0 65.0 62.0 68.0 57.0 53.0 62.0 56.0 59.0 53.0 71.0 59.0 50.0 62.0 53.0 60.0 74.0 74.0 62.0 62.0 59.0 65.0 47.0 47.0 47.0 62.0 41.0 62.0 68.0 65.0 0.0 62.0 59.0 65.0 53.0 50.0 62.0 59.0 62.0 56.0 50.0 62.0 50.0 50.0 50.0 59.0 54.0 85.0 85.0 59.0 53.0 56.0 44.0 59.0 62.0 56.0 62.0 59.0 59.0 56.0 57.0 62.0 0.0 18.0 29.0 62.0 56.0 56.0 59.0 53.0 53.0 59.0 71.0 56.0 56.0 56.0 53.0 53.0 74.0 71.0 56.0 53.0 62.0 44.0 62.0 65.0 59.0 62.0 62.0 59.0 56.0 65.0 59.0 18.0 0.0 32.0 65.0 56.0 59.0 56.0 53.0 53.0 62.0 74.0 56.0 59.0 56.0 56.0 56.0 74.0 74.0 62.0 56.0 56.0 44.0 58.0 68.0 67.0 59.0 59.0 59.0 59.0 62.0 65.0 29.0 32.0 0.0 57.0 56.0 56.0 68.0 56.0 56.0 56.0 71.0 56.0 56.0 59.0 57.0 50.0 76.0 76.0 59.0 65.0 62.0 62.0 50.0 47.0 54.0 71.0 50.0 56.0 65.0 68.0 53.0 62.0 65.0 57.0 0.0 62.0 68.0 68.0 50.0 71.0 56.0 50.0 59.0 62.0 56.0 59.0 61.0 82.0 85.0 59.0 56.0 56.0 56.0 60.0 53.0 53.0 54.0 56.0 56.0 59.0 57.0 50.0 56.0 56.0 56.0 62.0 0.0 50.0 65.0 53.0 59.0 59.0 71.0 47.0 53.0 62.0 62.0 54.0 76.0 76.0 53.0 47.0 53.0 56.0 54.0 68.0 56.0 63.0 50.0 56.0 58.0 53.0 62.0 56.0 59.0 56.0 68.0 50.0 0.0 65.0 50.0 59.0 59.0 71.0 53.0 59.0 62.0 49.0 56.0 75.0 74.0 65.0 62.0 65.0 62.0 65.0 71.0 65.0 65.0 65.0 62.0 62.0 62.0 59.0 59.0 56.0 68.0 68.0 65.0 65.0 0.0 59.0 47.0 65.0 74.0 65.0 59.0 59.0 59.0 68.0 79.0 79.0 59.0 59.0 53.0 47.0 56.0 71.0 62.0 59.0 56.0 53.0 59.0 56.0 62.0 53.0 53.0 56.0 50.0 53.0 50.0 59.0 0.0 59.0 50.0 62.0 53.0 59.0 55.0 56.0 53.0 76.0 74.0 62.0 56.0 56.0 59.0 59.0 65.0 61.0 62.0 53.0 59.0 59.0 59.0 56.0 53.0 53.0 56.0 71.0 59.0 59.0 47.0 59.0 0.0 65.0 74.0 59.0 50.0 56.0 59.0 58.0 76.0 76.0 59.0 53.0 62.0 56.0 47.0 56.0 56.0 59.0 50.0 59.0 62.0 53.0 50.0 59.0 62.0 56.0 56.0 59.0 59.0 65.0 50.0 65.0 0.0 56.0 47.0 59.0 43.0 59.0 53.0 79.0 79.0 62.0 68.0 71.0 62.0 57.0 53.0 65.0 71.0 44.0 68.0 71.0 71.0 62.0 71.0 74.0 71.0 50.0 71.0 71.0 74.0 62.0 74.0 56.0 0.0 59.0 71.0 59.0 60.0 65.0 88.0 85.0 56.0 50.0 59.0 50.0 50.0 59.0 50.0 65.0 44.0 62.0 59.0 59.0 50.0 56.0 56.0 56.0 59.0 47.0 53.0 65.0 53.0 59.0 47.0 59.0 0.0 62.0 56.0 56.0 56.0 79.0 74.0 59.0 59.0 56.0 51.0 59.0 65.0 59.0 62.0 53.0 50.0 59.0 50.0 50.0 56.0 59.0 56.0 62.0 53.0 59.0 59.0 59.0 50.0 59.0 71.0 62.0 0.0 53.0 56.0 54.0 76.0 76.0 59.0 50.0 58.0 53.0 56.0 56.0 50.0 68.0 43.0 62.0 56.0 62.0 50.0 56.0 56.0 59.0 56.0 62.0 62.0 59.0 55.0 56.0 43.0 59.0 56.0 53.0 0.0 56.0 53.0 74.0 74.0 50.0 56.0 53.0 53.0 50.0 65.0 56.0 62.0 59.0 56.0 59.0 53.0 59.0 53.0 56.0 57.0 59.0 62.0 49.0 59.0 56.0 59.0 59.0 60.0 56.0 56.0 56.0 0.0 53.0 76.0 74.0 50.0 53.0 63.0 50.0 49.0 68.0 50.0 58.0 56.0 58.0 56.0 60.0 54.0 53.0 56.0 50.0 61.0 54.0 56.0 68.0 53.0 58.0 53.0 65.0 56.0 54.0 53.0 53.0 0.0 72.0 69.0 62.0 68.0 74.0 68.0 82.0 88.0 79.0 70.0 76.0 79.0 21.0 74.0 85.0 74.0 74.0 76.0 82.0 76.0 75.0 79.0 76.0 76.0 79.0 88.0 79.0 76.0 74.0 76.0 72.0 0.0 35.0 59.0 71.0 79.0 65.0 80.0 88.0 76.0 76.0 74.0 79.0 41.0 74.0 85.0 71.0 74.0 76.0 85.0 76.0 74.0 79.0 74.0 76.0 79.0 85.0 74.0 76.0 74.0 74.0 69.0 35.0 0.0 #Sequence identities difference matrix of global PDB chains (%) 0.0 78.0 81.0 85.0 84.0 84.0 84.0 82.0 82.0 85.0 82.0 80.0 81.0 79.0 81.0 83.0 81.0 82.0 87.0 84.0 84.0 90.0 84.0 84.0 83.0 82.0 83.0 82.0 83.0 85.0 82.0 78.0 0.0 81.0 81.0 85.0 82.0 85.0 81.0 82.0 85.0 83.0 82.0 81.0 80.0 82.0 82.0 82.0 82.0 86.0 85.0 85.0 89.0 85.0 82.0 85.0 82.0 84.0 85.0 86.0 83.0 82.0 81.0 81.0 0.0 81.0 87.0 83.0 84.0 81.0 86.0 81.0 81.0 79.0 0.0 80.0 82.0 83.0 84.0 81.0 86.0 82.0 83.0 88.0 85.0 81.0 82.0 81.0 81.0 83.0 83.0 81.0 82.0 85.0 81.0 81.0 0.0 89.0 83.0 85.0 85.0 82.0 84.0 82.0 80.0 81.0 55.0 57.0 53.0 81.0 83.0 88.0 86.0 84.0 89.0 88.0 83.0 81.0 83.0 84.0 82.0 85.0 81.0 83.0 84.0 85.0 87.0 89.0 0.0 86.0 90.0 90.0 85.0 89.0 89.0 89.0 87.0 85.0 87.0 87.0 88.0 86.0 93.0 90.0 88.0 94.0 91.0 89.0 87.0 86.0 91.0 90.0 84.0 89.0 88.0 84.0 82.0 83.0 83.0 86.0 0.0 86.0 85.0 85.0 83.0 82.0 83.0 83.0 85.0 85.0 83.0 81.0 82.0 87.0 85.0 85.0 90.0 88.0 84.0 82.0 82.0 85.0 84.0 80.0 83.0 82.0 84.0 85.0 84.0 85.0 90.0 86.0 0.0 84.0 89.0 83.0 83.0 85.0 84.0 86.0 86.0 85.0 83.0 84.0 83.0 84.0 86.0 85.0 83.0 86.0 83.0 84.0 81.0 82.0 84.0 81.0 82.0 82.0 81.0 81.0 85.0 90.0 85.0 84.0 0.0 86.0 81.0 85.0 83.0 81.0 84.0 85.0 83.0 84.0 84.0 83.0 83.0 84.0 86.0 82.0 85.0 82.0 84.0 82.0 80.0 84.0 82.0 84.0 82.0 82.0 86.0 82.0 85.0 85.0 89.0 86.0 0.0 86.0 86.0 86.0 86.0 82.0 84.0 85.0 86.0 82.0 89.0 87.0 85.0 93.0 89.0 83.0 83.0 82.0 88.0 86.0 82.0 87.0 87.0 85.0 85.0 81.0 84.0 89.0 83.0 83.0 81.0 86.0 0.0 80.0 81.0 81.0 81.0 82.0 83.0 83.0 84.0 84.0 83.0 84.0 87.0 83.0 83.0 83.0 84.0 83.0 82.0 84.0 80.0 80.0 82.0 83.0 81.0 82.0 89.0 82.0 83.0 85.0 86.0 80.0 0.0 80.0 81.0 85.0 82.0 82.0 81.0 82.0 83.0 80.0 85.0 87.0 85.0 84.0 83.0 82.0 82.0 84.0 81.0 6.0 35.0 80.0 82.0 79.0 80.0 89.0 83.0 85.0 83.0 86.0 81.0 80.0 0.0 80.0 82.0 81.0 82.0 81.0 80.0 85.0 82.0 87.0 89.0 85.0 82.0 81.0 80.0 82.0 82.0 83.0 81.0 83.0 81.0 81.0 0.0 81.0 87.0 83.0 84.0 81.0 86.0 81.0 81.0 80.0 0.0 80.0 82.0 83.0 84.0 81.0 86.0 82.0 83.0 88.0 85.0 81.0 82.0 81.0 81.0 83.0 83.0 81.0 82.0 79.0 80.0 80.0 55.0 85.0 85.0 86.0 84.0 82.0 81.0 85.0 82.0 80.0 0.0 30.0 40.0 82.0 83.0 87.0 84.0 86.0 89.0 88.0 82.0 84.0 83.0 84.0 81.0 82.0 83.0 82.0 81.0 82.0 82.0 57.0 87.0 85.0 86.0 85.0 84.0 82.0 82.0 81.0 82.0 30.0 0.0 40.0 81.0 82.0 86.0 85.0 83.0 89.0 85.0 83.0 84.0 82.0 84.0 85.0 82.0 84.0 84.0 83.0 82.0 83.0 53.0 87.0 83.0 85.0 83.0 85.0 83.0 82.0 82.0 83.0 40.0 40.0 0.0 82.0 82.0 87.0 86.0 82.0 90.0 88.0 81.0 80.0 82.0 84.0 81.0 82.0 83.0 83.0 81.0 82.0 84.0 81.0 88.0 81.0 83.0 84.0 86.0 83.0 81.0 81.0 84.0 82.0 81.0 82.0 0.0 81.0 85.0 83.0 82.0 89.0 86.0 84.0 84.0 81.0 83.0 81.0 83.0 81.0 79.0 82.0 82.0 81.0 83.0 86.0 82.0 84.0 84.0 82.0 84.0 82.0 80.0 81.0 83.0 82.0 82.0 81.0 0.0 88.0 85.0 84.0 90.0 85.0 85.0 83.0 0.0 83.0 83.0 81.0 82.0 81.0 87.0 86.0 86.0 88.0 93.0 87.0 83.0 83.0 89.0 84.0 83.0 85.0 86.0 87.0 86.0 87.0 85.0 88.0 0.0 82.0 88.0 85.0 82.0 87.0 86.0 88.0 85.0 84.0 88.0 83.0 83.0 84.0 85.0 82.0 86.0 90.0 85.0 84.0 83.0 87.0 83.0 80.0 82.0 82.0 84.0 85.0 86.0 83.0 85.0 82.0 0.0 84.0 85.0 83.0 84.0 85.0 85.0 81.0 84.0 85.0 80.0 82.0 84.0 85.0 83.0 84.0 88.0 85.0 86.0 84.0 85.0 84.0 85.0 87.0 83.0 86.0 83.0 82.0 82.0 84.0 88.0 84.0 0.0 89.0 86.0 83.0 84.0 84.0 83.0 83.0 85.0 83.0 81.0 90.0 89.0 88.0 89.0 94.0 90.0 85.0 86.0 93.0 87.0 87.0 89.0 88.0 89.0 89.0 90.0 89.0 90.0 85.0 85.0 89.0 0.0 85.0 90.0 88.0 90.0 85.0 89.0 90.0 88.0 88.0 84.0 85.0 85.0 88.0 91.0 88.0 83.0 82.0 89.0 83.0 85.0 85.0 85.0 88.0 85.0 88.0 86.0 85.0 82.0 83.0 86.0 85.0 0.0 85.0 85.0 85.0 84.0 85.0 88.0 84.0 85.0 84.0 82.0 81.0 83.0 89.0 84.0 86.0 85.0 83.0 83.0 84.0 82.0 81.0 82.0 83.0 81.0 84.0 85.0 87.0 84.0 83.0 90.0 85.0 0.0 88.0 86.0 84.0 84.0 86.0 85.0 84.0 83.0 85.0 82.0 81.0 87.0 82.0 83.0 82.0 83.0 83.0 83.0 81.0 82.0 84.0 84.0 80.0 84.0 83.0 86.0 85.0 84.0 88.0 85.0 88.0 0.0 83.0 81.0 83.0 82.0 85.0 81.0 82.0 82.0 81.0 83.0 86.0 82.0 84.0 84.0 82.0 84.0 82.0 80.0 81.0 83.0 82.0 82.0 81.0 0.0 88.0 85.0 84.0 90.0 85.0 86.0 83.0 0.0 83.0 83.0 81.0 82.0 81.0 83.0 84.0 81.0 84.0 91.0 85.0 81.0 82.0 88.0 83.0 82.0 82.0 81.0 84.0 84.0 84.0 83.0 83.0 85.0 81.0 83.0 85.0 84.0 84.0 81.0 83.0 0.0 82.0 85.0 82.0 81.0 82.0 85.0 83.0 82.0 90.0 84.0 82.0 80.0 86.0 82.0 84.0 82.0 83.0 81.0 85.0 81.0 81.0 83.0 84.0 84.0 83.0 89.0 85.0 84.0 83.0 83.0 82.0 0.0 83.0 82.0 83.0 83.0 86.0 83.0 85.0 84.0 80.0 84.0 84.0 82.0 84.0 81.0 83.0 83.0 82.0 82.0 82.0 83.0 81.0 88.0 85.0 85.0 90.0 88.0 86.0 82.0 81.0 85.0 83.0 0.0 82.0 84.0 85.0 83.0 81.0 81.0 89.0 83.0 81.0 82.0 87.0 80.0 6.0 81.0 81.0 83.0 84.0 83.0 81.0 82.0 83.0 80.0 83.0 88.0 84.0 85.0 85.0 82.0 82.0 82.0 82.0 0.0 36.0 82.0 82.0 82.0 83.0 88.0 82.0 82.0 84.0 87.0 80.0 35.0 83.0 82.0 82.0 84.0 83.0 79.0 81.0 83.0 82.0 81.0 88.0 85.0 84.0 81.0 81.0 81.0 83.0 84.0 36.0 0.0 #FASTA SCORE matrix of loop sequence - 14 13 19 4 -4 -4 -8 5 13 11 5 -3 7 -1 8 6 6 4 -5 10 -2 10 15 9 2 - 13 -6 16 12 - - 17 16 3 - -7 -3 11 6 6 7 4 8 - 9 5 13 2 -2 9 -1 16 11 16 4 -5 6 -6 11 7 - - - 13 4 3 2 -3 11 4 4 7 6 11 3 12 4 12 3 -3 8 2 8 9 13 4 -7 4 -11 9 4 - - - - 2 -5 -4 -7 7 11 12 6 - 6 -2 7 4 13 2 -3 8 -3 12 17 16 3 1 11 -4 17 14 - - - - - -5 -7 -10 3 5 -1 5 -5 7 -1 6 15 4 18 -5 13 4 - 1 2 8 -8 6 -12 - - - - - - - - 10 - 2 3 -6 -9 12 14 16 5 3 10 -8 7 -7 8 -7 -5 3 3 6 -7 -12 -9 -4 - - - - - - - -7 -7 3 -5 -12 7 5 7 -4 1 3 -9 - -9 - -9 -6 -3 -1 6 -7 -9 -8 -5 - - - - - - - - -2 -7 - -1 1 -6 -3 -7 -7 -1 -11 4 -9 -6 -11 -10 -2 -5 -1 -7 -12 - -2 - - - - - - - - - 4 3 4 4 10 2 9 4 13 3 - 4 1 5 16 12 9 -2 5 -7 3 5 - - - - - - - - - - 13 1 6 14 6 5 19 14 3 5 9 -2 4 9 9 11 9 16 -8 10 14 - - - - - - - - - - - 10 -2 5 -3 3 6 7 - 3 4 -7 4 10 12 6 4 10 -8 19 22 - - - - - - - - - - - - -5 2 -6 4 8 4 3 2 17 3 10 9 5 13 -8 1 -12 13 8 - - - - - - - - - - - - - 10 17 1 6 15 -8 15 -4 9 -3 -3 8 6 5 -4 -10 -5 -1 - - - - - - - - - - - - - - 22 21 15 18 5 9 5 9 4 6 11 14 3 4 -10 2 7 - - - - - - - - - - - - - - - 13 7 10 -3 16 -3 16 -4 -2 3 6 5 -4 -10 -6 -1 - - - - - - - - - - - - - - - - 6 9 5 - 7 8 6 8 9 5 -6 4 -9 3 5 - - - - - - - - - - - - - - - - - 14 8 6 19 5 2 2 8 18 2 9 -11 3 7 - - - - - - - - - - - - - - - - - - 1 10 4 2 6 6 21 15 4 4 -9 4 9 - - - - - - - - - - - - - - - - - - - -7 8 - -1 1 2 4 -10 10 -10 - 1 - - - - - - - - - - - - - - - - - - - - -4 8 -6 -5 3 9 6 -5 -12 - 7 - - - - - - - - - - - - - - - - - - - - - 2 11 11 6 8 -8 9 -10 7 5 - - - - - - - - - - - - - - - - - - - - - - -3 -3 -1 8 -3 -5 -11 -7 -5 - - - - - - - - - - - - - - - - - - - - - - - 14 9 2 -7 4 -5 7 5 - - - - - - - - - - - - - - - - - - - - - - - - 9 5 3 9 -5 13 12 - - - - - - - - - - - - - - - - - - - - - - - - - 8 -1 6 -8 7 14 - - - - - - - - - - - - - - - - - - - - - - - - - - 11 1 -11 3 7 - - - - - - - - - - - - - - - - - - - - - - - - - - - -1 -6 1 5 - - - - - - - - - - - - - - - - - - - - - - - - - - - - -6 10 11 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -8 -7 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 17 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - #FASTA SCORE matrix of motif sequence - 38 11 18 26 -5 -6 -21 3 21 31 -13 -14 -2 - -11 12 3 -17 -11 5 -11 -4 7 17 -10 -15 10 -13 36 43 - - 2 14 8 2 -22 -14 10 3 13 -3 -3 6 7 -2 1 16 7 8 8 2 16 10 22 -3 -3 -14 -26 18 16 - - - - 29 -3 14 -1 10 11 8 8 10 - -7 -7 16 -6 -8 -15 28 -10 -6 -7 4 2 -26 12 -25 13 -7 - - - - -8 -12 -22 16 17 - 11 9 -4 47 39 44 -4 7 -7 -1 21 -3 13 36 19 -1 -2 -8 -7 16 31 - - - - - -12 -11 -14 -1 7 -5 -5 8 2 -2 -6 14 -13 -2 -16 5 1 1 -10 3 -6 -30 20 - -4 -8 - - - - - - 16 -9 5 -13 -12 -20 8 9 4 -11 7 20 -17 -7 -25 5 -16 -5 1 -4 -5 -11 -11 -15 -7 - - - - - - - -20 -16 -21 -12 -31 2 -10 -9 -25 -8 -2 -19 -25 -22 -14 -28 -23 -19 -13 -11 -16 -9 -15 -4 - - - - - - - - - -2 -20 -13 -2 4 -2 2 -4 -4 -23 -6 -1 -5 -12 1 -14 -9 -16 -5 -28 -16 -8 - - - - - - - - - -1 -3 19 15 5 -4 1 10 14 12 1 -5 6 -9 11 25 16 -7 -7 -10 -3 4 - - - - - - - - - - 10 9 -12 12 14 4 29 18 -5 -8 24 -4 12 9 8 15 -11 -4 -11 7 3 - - - - - - - - - - - 10 -21 7 3 -1 5 6 -17 7 2 -4 -10 7 10 -2 3 -6 -16 123 87 - - - - - - - - - - - - -14 -6 -15 -1 6 -8 16 -5 19 12 19 - 1 26 -14 -12 -21 13 8 - - - - - - - - - - - - - 3 5 -14 -4 18 -20 17 -11 13 -12 -20 16 15 -11 -8 -6 -24 -17 - - - - - - - - - - - - - - 104 78 - 12 -10 1 9 11 2 13 13 1 -4 -8 -7 4 22 - - - - - - - - - - - - - - - 62 -6 5 -17 6 8 14 -3 7 8 -10 -5 -15 -13 - 15 - - - - - - - - - - - - - - - - -5 1 -10 -11 9 7 1 14 4 -3 -12 -14 -14 -1 15 - - - - - - - - - - - - - - - - - 13 2 - 35 -3 -23 -1 2 13 -15 -1 -18 2 -1 - - - - - - - - - - - - - - - - - - -10 -3 9 6 -5 10 33 14 -6 -17 -19 3 9 - - - - - - - - - - - - - - - - - - - -18 11 -11 -12 - -2 -2 -24 -3 -12 -17 -10 - - - - - - - - - - - - - - - - - - - - 4 40 -21 -3 2 - 4 -31 -27 4 11 - - - - - - - - - - - - - - - - - - - - - -7 19 24 13 10 -17 -5 -27 5 4 - - - - - - - - - - - - - - - - - - - - - - -12 -13 3 12 4 -8 -30 -4 -3 - - - - - - - - - - - - - - - - - - - - - - - 12 3 -12 -7 -19 -17 -7 -5 - - - - - - - - - - - - - - - - - - - - - - - - 3 -13 -12 -10 4 10 14 - - - - - - - - - - - - - - - - - - - - - - - - - -9 -16 -1 -20 5 15 - - - - - - - - - - - - - - - - - - - - - - - - - - 8 2 -20 -5 -1 - - - - - - - - - - - - - - - - - - - - - - - - - - - -14 -4 - 13 - - - - - - - - - - - - - - - - - - - - - - - - - - - - -10 -6 -1 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -16 -3 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 111 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - #FASTA SCORE matrix of global PDB chain sequence - 182 -14 -38 -207 -107 -280 -218 -153 -160 -123 -29 -14 -25 7 5 -32 -31 -620 -211 -54-1150 -431 -44 -93 -31 -204 -111 -130 -111 -119 - - -10 -51 -248 -87 -275 -192 -121 -149 -131 -58 -10 -15 -17 -45 -41 -84 -620 -219 -83-1133 -464 -56 -90 -84 -199 -146 -139 -115 -98 - - - -75 -335 -105 -241 -158 -214 -48 -52 -55 2248 -68 -64 -94 - -49 -572 -173 -72-1067 -409 -83 -63 -49 -113 -101 -139 -48 -72 - - - - -248 -31 -388 -258 -105 -185 -152 -116 -75 763 682 763 -47 -85 -691 -277 -137-1200 -551 -46 -42 -85 -232 -106 -139 -149 -150 - - - - - -209 -644 -594 -82 -433 -406 -364 -335 -204 -217 -224 -313 -219-1056 -595 -307-1612 -825 -278 -274 -219 -523 -395 -175 -417 -429 - - - - - - -359 -296 -125 -177 -175 -151 -105 -69 -63 -45 -60 -29 -709 -338 -108-1258 -549 -81 -43 -29 -258 -169 -85 -161 -192 - - - - - - - -146 -536 -177 -182 -239 -241 -390 -353 -381 -269 -253 -297 -109 -277 -681 -153 -307 -279 -253 -85 -193 -363 -141 -187 - - - - - - - - -421 -104 -167 -199 -158 -275 -251 -296 -203 -241 -260 -113 -228 -735 -120 -248 -222 -241 -89 -103 -356 -171 -170 - - - - - - - - - -324 -303 -240 -214 -111 -147 -126 -227 -148 -838 -429 -190-1387 -684 -99 -182 -148 -413 -283 -93 -298 -298 - - - - - - - - - - -43 -103 -48 -156 -180 -201 -109 -146 -291 -120 -130 -909 -315 -101 -137 -146 -129 -102 -215 -46 -93 - - - - - - - - - - - -84 -52 -167 -177 -148 -103 -123 -423 -146 -147 -910 -300 -126 -154 -123 -134 -78 -215 2469 1736 - - - - - - - - - - - - -55 -102 -119 -111 -77 -69 -499 -238 -113-1025 -381 -110 -58 -69 -108 -107 -127 -75 -73 - - - - - - - - - - - - - -68 -64 -94 - -49 -572 -173 -72-1067 -409 -83 -63 -49 -113 -101 -139 -48 -72 - - - - - - - - - - - - - - 1226 1058 -58 -76 -685 -309 -116-1247 -563 -23 -57 -76 -250 -111 -96 -161 -152 - - - - - - - - - - - - - - - 1089 -56 -37 -658 -251 -115-1225 -501 -60 -57 -37 -241 -121 -80 -169 -166 - - - - - - - - - - - - - - - - -82 -85 -721 -327 -129-1230 -553 1 -69 -85 -244 -102 -92 -147 -149 - - - - - - - - - - - - - - - - - -42 -556 -233 -81-1092 -451 -67 -66 -42 -179 -102 -151 -96 -73 - - - - - - - - - - - - - - - - - - -666 -324 -91-1162 -425 -57 -63 1939 -190 -93 -53 -141 -134 - - - - - - - - - - - - - - - - - - - -259 -611 -370 -138 -665 -630 -666 -368 -472 -758 -436 -381 - - - - - - - - - - - - - - - - - - - - -220 -730 -179 -259 -248 -324 -80 -205 -372 -139 -118 - - - - - - - - - - - - - - - - - - - - --1119 -393 -72 -97 -91 -172 -141 -141 -137 -129 - - - - - - - - - - - - - - - - - - - - - - -518-1127-1153-1162 -814-1032-1285 -919 -937 - - - - - - - - - - - - - - - - - - - - - - - -451 -414 -425 -233 -315 -598 -311 -334 - - - - - - - - - - - - - - - - - - - - - - - - -67 -57 -237 -78 -114 -108 -108 - - - - - - - - - - - - - - - - - - - - - - - - - -63 -163 -125 -118 -138 -140 - - - - - - - - - - - - - - - - - - - - - - - - - - -190 -93 -53 -141 -134 - - - - - - - - - - - - - - - - - - - - - - - - - - - -98 -331 -95 -108 - - - - - - - - - - - - - - - - - - - - - - - - - - - - -228 -51 -86 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -197 -212 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 1706 - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -